Uncontrolled IL-1ß: The Underlying Cause
Mutated cryopyrin found in CAPS sufferers stimulates a certain type of white blood cell to overproduce IL-1ß. This activity is often triggered by cold temperature.
When a trigger is present, cryopyrin assembles with other molecules to coordinate an inflammatory response. This response causes overproduction of IL-1ß, which leads to inflammation, resulting in the symptoms seen in CAPS.
