CAPS Family Connections

NOMID (Neonatal-Onset Multisystem Inflammatory Disease): An Overview

NOMID stands for Neonatal-Onset Multisystem Inflammatory Disease.

NOMID (neonatal-onset multisystem inflammatory disease) is the most severe type of CAPS (cryopyrin-associated periodic syndrome). All of the symptoms of MWS (Muckle-Wells Syndrome) may be experienced by patients suffering from NOMID (neonatal-onset multisystem inflammatory disease), but these symptoms are felt all the time and more severely.

Additional symptoms include:

• Gradual loss of eyesight
• Swelling of the knees
• Mental disability

NOMID (neonatal-onset multisystem inflammatory disease) manifests itself at birth. In fact, there is a chance of inflammation developing in the mother's womb and doctors have observed evidence of inflamed umbilical cords.

Babies with NOMID (neonatal-onset multisystem inflammatory disease) have a persistent rash. They also can have joint swelling and disfiguring changes to the growth cartilage, often at the knees. It is typical to see decreased muscle tone and lax muscles, sometimes leading to the inability to walk or bear weight on the legs. In some NOMID (neonatal-onset multisystem inflammatory disease) patients, aseptic meningitis leads to seizures and developmental delay.