FCAS: An Overview

FCAS stands for Familial Cold Autoinflammatory Syndrome.

FCAS is the least severe type of CAPS. Most people with FCAS face limitations in daily life but have a normal life expectancy. They often marry and have children (which is how the gene for FCAS is passed on, although a gene can mutate spontaneously). Symptoms include:

  • Recurring rash
  • Fever
  • Feeling tired
  • Pain in the joints
  • Headache
  • Chills
  • Sore or red eyes
  • Pain in the muscles

Rash usually appears 1 to 2 hours after being exposed to cold temperatures. Some patients have evidence of rash almost daily. About 4 to 6 hours after exposure, the patient generally develops a low-grade fever and joint pains. Most episodes last less than 24 hours and may also include sweating, extreme thirst, and nausea.